Barbiturate Poisoning Treated with Picrotoxin

Effect of analeptics on brain pentobarbital levels and sleeping time in mice.

IN THE treatment of barbiturate poisoning the therapeutic emphasis has shifted from the use of analeptics and efforts at arousal to a regimen of physiologic supportive therapy.1 For some time, though, analeptics were drugs of choice, the results being transferred from experimental evidenceQ* 3 despite some reports49 5 about the ineffectiveness of these drugs in animals given large doses of barb...

Prolonged Coma in Barbiturate Poisoning

In 1954 the recorded deaths from barbiturate poisoning in England and ^ were 574 and non-fatal cases were assessed as 6,000 (Locket, 1956). In spite of large number of reported cases in the literature, there were few in which coma1 prolonged for more than a week. The Medical Journal of Australia (1934) menti"' a case of ten days' duration, McElligott (1955) cited another of ten days, Shulman^ (...

Electrochemical Oxidation and Molecular Docking Studies of Leaves Extract of Lemon Verbena and Flowers Extract of Echium Amoenum: Green Antidotes for Treatment of Barbiturate Poisoning

Electrochemical oxidation of leaves extract of lemon verbena and the flowers extract of echium amoenum have been studied in the absence and presence of barbituric acid and 1,3 dimethyl barbituric acidin aqueous solutions and biological pH, using cyclic voltammetry method. The results showed that the electrochemically generated compounds in leaves extract of lemon verbena and the flowers extract...

[Mixed salicylate and barbiturate medicamentous poisoning. Experimental study].

Severe barbiturate and paracetamol overdose: the simultaneous removal of both poisons by haemoperfusion.

Charcoal haemoperfusion was successful in the treatment of severe butobarbitone poisoning complicated by resistant hypotension. At the same time the rapid removal of paracetamol may have lessened the severity of the subsequent hepatic injury. The mechanism and management of shock associated with barbiturate poisoning, and the possible application of haemoperfusion in paracetamol poisoning are d...